Buffalo & Amherst: 716.881.7900

Orchard Park: 716.677.6500

Buffalo & Amherst: 716.881.7900
Orchard Park: 716.677.6500
Jack Sullivan, MD, PhD - Electrophysiology and Hereditary Retina

Jack Sullivan, MD, PhD

Electrophysiology and Hereditary Retina

Veterans Administration WNY Healthcare System,
Building 20, Room 245
3495 Bailey Ave.
Buffalo, NY 14215
Phone: 716-862-6533
Email: jackmsullivanmdphd@yahoo.com

M.D., Ph.D., Mount Sinai School of Medicine, New York, NY

Internship (Internal Medicine):
St. John’s Mercy Medical Center, St. Louis, MO

Fellowship (Hereditary Retinal and Macular Disease):
University of Michigan, Ann Arbor, MI

Residency (Ophthalmology and Neurobiology):
Washington University School of Medicine, St. Louis, MO

Titles and Departments:
Associate Professor, Department of Ophthalmology
Adjunct Associate Professor, Departments of Physiology & Biophysics, Pharmacology and Toxicology, and Neuroscience Program

Research Interest:

Dr. Jack Sullivan, M.D., Ph.D. focuses his lab research on development of gene-based therapeutics for retinal and macular degenerations. In autosomal dominant genetic diseases post-transcriptional gene silencing (PTGS) agents, such as ribozymes or RNAi, can be used to suppress toxic target gene expression and ameliorate cellular stresses to promote increased functional vitality and survival. Such PTGS agents may also be used to alter normal gene expression systems (e.g., metabolic pathways) to slow the rate of temporally emergent diseases (e.g., age-related macular degeneration). Development of PTGS agents is befit with multi-level biocomplexity, which has markedly curtailed clinical translation of PTGS RNA drugs.

We developed an RNA Drug Discovery technology platform to relieve established bottlenecks that limit PTGS discovery. This platform allows rigorous evaluation of target mRNA accessibility, screening of many potential PTGS agents to identify a lead RNA drug candidate, optimization of this lead drug, and cellular toxicity determinations prior to animal experiments. We used this platform to develop potent ribozyme and RNAi agents against a particular disease target underlying autosomal dominant retinitis pigmentosa, and are now conducting a preclinical gene therapy trial of these agents in target-humanized mouse models of retinal degeneration. We are extending RNA Drug Discovery to validated targets in age-related macular degeneration.

Our studies employ a multidisciplinary approach of biophysics, bioengineering, molecular biology, molecular genetics, bioinformatics, and novel instrumentation and technology design. Our long-term goal is to translate successful RNA Drug Discovery into human clinical trials for people who suffer on a daily basis from visual loss due to these disease states.

Ross Eye Footer Logo
UBMD Physicians' Group Logo in White

Buffalo Niagara
Medical Campus

1176 Main St.
Buffalo, NY 14209
P: 716-881-7900
F: 716-881-4349

Office Hours:
M-F 8a.m. - 4:30p.m.

Get Directions »
Request an Appointment »

Northtowns Office

3580 Sheridan Drive
Suite 150
Amherst, NY 14226
P: 716-881-7900
F: 716-833-4916

Office Hours:
M-F 8a.m. - 4:30p.m.

Get Directions »
Request an Appointment »

Southtowns Office

301 Sterling Drive
Orchard Park, NY 14127
P: 716-677-6500
F: 716-677-6507

Office Hours:
M-F 8a.m. - 4:30p.m.

Get Directions »
Request an Appointment »

Your vision is of utmost importance to us.

At the Ross Eye Institute, we understand the importance of continuing to meet your vision care needs. We take your health and COVID-19 precautions very seriously. Your health, and ours is of utmost importance.

- We follow the Department of Health guidelines.
- Doctors and staff undergo daily screening questions as well as temperature checks twice a day.
- Access to our facility is limited to our patients only. If a patient cannot attend their appointment on their own, an escort will also be permitted.
- Patients who arrive more than 15 minutes prior to their appointment will not be allowed inside until it gets closer to their scheduled appointment time. Please plan accordingly.
- Patient and staff touch points are sanitized between each use and logs are maintained documenting strict adherence.
- Proper mask use is strictly enforced.
- We are not allowing visits from pharmaceutical reps, vendors, or other salespersons or business associates.

Your vision care is a critical component to maintaining long-term vision health and the Ross Eye Institute remains committed to meeting your vision care needs while keeping you safe, during these uncertain times.