Josh J. Wang, MD, MS
Vision Research Center
1176 Main St.
Buffalo, NY 14209
Title and Department:
Associate Professor of Research
Ophthalmology and Internal Medicine
Education and Training:
M.D. Yunyang Medical College, Tongji University of Medical Sciences, Hubei, China
M.S. (Medicine-Cardiology) Sun Yat-sen University of Medical Sciences, Guangzhou, China
Clinical Fellowship (Cardiology):
The First People’s Hospital of Guangzhou, Guangzhou, China
Residency (Internal Medicine):
Yunyang Medical College-University Hospital, Tongji University of Medical Sciences, Hubei, China
Medical University of South Carolina, Charleston, SC (Ophthalmology/Molecular Biology)
University of Oklahoma Health Sciences Center, Oklahoma City, OK (Medicine/Cell Biology)
Collaborative clinical and epidemiological research/clinical trials, fundamental retinal processes, retinal diseases
Age-related macular degeneration, diabetic retinopathy, vascular diseases
Synopsis of Research:
Dr. Josh J. Wang, M.D., M.S. focuses his research on studying diabetic-related vascular complications, including diabetic retinopathy, diabetic vascular disease, insulin resistance and diabetic nephropathy. In addition to addressing mechanisms, our cellular and biochemical studies are meant to develop cures for diseases that affect the retina, peripheral vessel and kidney.
1. Diabetic retinopathy: Focusing on endoplasmic reticulum (ER) stress activation and interactions among ER stress, oxidative stress and inflammation in retina.
2. Periphral vascular disease (PVD): Endothelial cells in the vascular system are especially vulnerable to hyperglycemic conditions. Exploring endothelial dysfunction in diabetic setting, would aid in the search for novel approaches in the prevention of diabetes vascular disease.
3. Diabetic nephropathy: Glomerular endothelial cells and podocytes are primary sites of injury resulting in chronic kidney disease in diabetes. We investigate the function of endogenous angiogenic inhibitors in regulation of renal cells in diabetic kidney.
4. Adipocyte and insulin resistance: Studying the function of PEDF in adipogenesis, provide pivotal information for understanding the mechanisms underlying the association of PEDF, obesity and insulin resistance.