Buffalo & Amherst: 716.881.7900

Orchard Park: 716.677.6500

Buffalo & Amherst: 716.881.7900
Orchard Park: 716.677.6500
info@rosseyeinstitute.com
Sarah Xin Zhang, MD - Vision Research Center

Margaret M. DeAngelis, PhD

Vision Research Center

Contact:
3495 Bailey Ave.
Buffalo, NY 14215
Email: mmdeange@buffalo.edu

Title and Department:
Professor, Ophthalmology

Education and Training:
Ph.D. Neuroscience, Louisiana State University Health Sciences Center
M.S. Physiology, Medical College of Virginia
Certification, Statistics, Rockefeller University

Fellowship (Human Genetics, Statistics, Bioinformatics, Ophthalmology, Epidemiology):
Harvard Medical School/MEEI

Research Focus:

Systems biology-based approach to understanding disease mechanisms in both Mendelian and complex blinding diseases 

Clinical Relevance:

Age-related macular degeneration

Synopsis of Research:

Utilizing both families and then replication in large case-control populations to study DNA, gene expression and protein coupled with epidemiological information, our group has identified novel biomarkers (RORA, ROBO1, CYP24A1) and pathways associated with age-related macular degeneration and then replicated these findings in large ethnically diverse case control patient populations. We demonstrated that RORA, an intracellular target of cholesterol, interacted with other established AMD genetic risk factors (ARMS2/HTRA1) thus furthering the development of a unifying hypothesis underlying AMD pathophysiology. To enhance our translational efforts, in 2013, our laboratory and team of ophthalmologists created a well characterized fresh human donor eye bank of tissue, blood, serum and plasma from private foundation grants awarded to Dr. DeAngelis. The creation of a well characterized fresh donor eye repository by our group to study healthy eyes compared to disease states including, AMD, has enabled us to employ and develop genome wide level multi-omic approaches, including miRNAseq, RNASeq, RNA- single nuclei-Seq, allele specific expression, epigenetic, and statistical/bioinformatic tools to delineate disease mechanism. This is done in an effort to develop appropriate therapeutic targets and biomarkers for the different clinical stages of blinding disease. currently there are no cures for age-related macular degeneration.

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Buffalo Niagara
Medical Campus

1176 Main St.
Buffalo, NY 14209
P: 716-881-7900
F: 716-881-4349

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Northtowns Office

3580 Sheridan Drive
Suite 150
Amherst, NY 14226
P: 716-881-7900
F: 716-833-4916

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Your vision is of utmost importance to us.

At the Ross Eye Institute, we understand the importance of continuing to meet your vision care needs. We take your health and COVID-19 precautions very seriously. Your health, and ours is of utmost importance.

- We follow the Department of Health guidelines.
- Doctors and staff undergo daily screening questions as well as temperature checks twice a day.
- Access to our facility is limited to our patients only. If a patient cannot attend their appointment on their own, an escort will also be permitted.
- Patients who arrive more than 15 minutes prior to their appointment will not be allowed inside until it gets closer to their scheduled appointment time. Please plan accordingly.
- Patient and staff touch points are sanitized between each use and logs are maintained documenting strict adherence.
- Proper mask use is strictly enforced.
- We are not allowing visits from pharmaceutical reps, vendors, or other salespersons or business associates.

Your vision care is a critical component to maintaining long-term vision health and the Ross Eye Institute remains committed to meeting your vision care needs while keeping you safe, during these uncertain times.