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The Ross Eye Institute Vision Research Center

Looking to the future: Research at The Ross

Research at the Ross Vision Research CenterThe Ross Eye Institute Vision Research Center

Part of the Ross Eye Institute, the UB Department of Ophthalmology is committed to excellence in research, medical education, and healthcare.

Our research leads to sight-preserving treatments for conditions and diseases such as age-related macular degeneration, diabetic retinopathy and glaucoma. Our goal is to reduce visual impairment and improve the quality of life for people of all ages.

Ross researchers collaborate with scientists from over a dozen other universities, as well as domestic and international private research institutes and pharmaceutical companies. We also participate in the SUNY Eye Institute, a SUNY-wide eye research consortium represented by the four SUNY medical centers and the College of Optometry.

Our Research Faculty

Click on any doctor’s photo to learn more about their research and our laboratory efforts.

Dr. Steven J. Fliesler

Steven J. Fliesler,
PhD

Dr. Xiuqian Mu

Xiuqian Mu,
MD, PhD

Dr. Sangita Patel

Sangita Patel,
MD, PhD

Dr. Jack Sullivan

Jack Sullivan,
MD, PhD

Dr. Josh J. Wang

Josh J. Wang,
MD, MS

Dr. Sarah Xin Zhang

Sarah Xin Zhang,
MD

Distinguished Lectures in Vision Science 2019-2020

These lectures will be held in 2019 and 2020 on Thursdays, at 4:00 pm, Rm 2220A (2nd Floor- Ronald L. Dozoretz, MD, Auditorium)
Jacobs School of Medicine and Biomedical Sciences, 955 Main Street, Buffalo, NY.

SEPTEMBER 19, 2019 – Artur V. Cideciyan, PhD., Research Professor of Ophthalmology, Scheie Eye Institute / Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
Web: https://www.med.upenn.edu/cideciyanlab
PubMed: https://www.ncbi.nlm.nih.gov/pubmed/?term=Cideciyan+AV
Lecture Title: TBA
Host: Jack M. Sullivan, MD, PhD

OCTOBER 3, 2019 (*revised date) – Louis R. Pasquale, MD, FARVO Professor, Department of Ophthalmology, Vice Chair of Translational Ophthalmology Research, Icahn School of Medicine at Mount Sinai, Site Chair of Ophthalmology / Mt. Sinai Hospital, New York, NY
Web: https://icahn.mssm.edu/research/eye-vision-institute/faculty
PubMed: https://www.ncbi.nlm.nih.gov/pubmed/?term=Pasquale+LR
Lecture Title: TBA
Host: Asher Weiner, MD

NOVEMBER 14, 2019 – Leonard A. Levin, MD, PhD, FRCSC, FARVO, Professor and Chair of Ophthalmology, Riva and Thomas O. Hecht Family Chair in Ophthalmology, Professor of Neurology & Neurosurgery, Canada Research Chair in Translational Visual Science McGill University, Montreal, Québec (Canada)
Web: https://www.mcgill.ca/neuro/research/researchers/levin
PubMed: https://www.ncbi.nlm.nih.gov/pubmed/?term=Levin+Leonard+A
Lecture Title: TBA
Host: Sandra F. Sieminski, MD

FEBRUARY 20, 2020 – Patsy M. Nishina, PhD., Professor The Jackson Laboratory, Bar Harbor, ME
Web: https://www.jax.org/research-and-faculty/faculty/patsy-nishina
PubMed: https://www.ncbi.nlm.nih.gov/pubmed/?term=Nishina+PM
Lecture Title: TBA
Host: Sarah X. Zhang, PhD

MARCH 19, 2020 Stephen P. Daiger, PhD., T.S. Matney Professor in Environmental and Genetic Sciences, Human Genetics Center, School of Public Health and Mary Farish Johnston Distinguished Chair in Ophthalmology, Ruiz Department of Ophthalmology and Visual Science, The University of Texas HSC at Houston, Houston, TX
Web: https://sph.uth.edu/retnet/sdaiger.htm
PubMed: https://www.ncbi.nlm.nih.gov/pubmed/?term=Daiger+SP
Lecture Title: TBA
Host: Michael H. Farkas, PhD

APRIL 16, 2020 – Michael A. Dyer, PhD, Investigator, Howard Hughes Medical Institute Member, St. Jude Faculty Chair, Developmental Neurobiology Department, St. Jude Children’s Research Hospital, Memphis, TN
Web: https://www.stjude.org/directory/d/michael-dyer.html
PubMed: https://www.ncbi.nlm.nih.gov/pubmed/?term=Dyer+Michael+A
Lecture Title: TBA
Host: Xiuqian Mu, MD, PhD

MAY 21, 2020 – Michael P. Fautsch, Ph.D., Professor Departments of Ophthalmology and Biochemistry & Molecular Biology, Mayo Clinic, College of Medicine, Rochester, MN
Web: https://www.mayo.edu/research/faculty/fautsch-michael-p-ph-d/bio-00026344
PubMed: https://www.ncbi.nlm.nih.gov/pubmed/?term=Fautsch+MP
Lecture Title: TBA
Host: Sangita P. Patel, MD, Ph.D.

Summary of Research Programs

Fliesler Lab Research

Our lab is focused on studies of retinal degenerations caused by defects in isoprenoid biosynthesis. Our primary focus concerns how defective cholesterol metabolism (e.g., Smith-Lemli-Opitz syndrome, or SLOS) affects the development and maintenance of normal retinal structure and function, using pharmacological and transgenic animal models. In addition, we are studying how defects in dolichol synthesis impact retinal structure and function, using novel genetic mouse models of RP59 that have either a mutation in, or deletion of, the gene that encodes DHDDS (dehydrodolicholdiphosphate synthase), which is required for dolichol synthesis and, hence, N-linked protein glycosylation. We also are studying the effects of acoustic blast overpressure on the structure and function of the retina, using a rat model that mimics mild traumatic brain injury (mTBI).