The Ross Eye Institute Vision Research CenterLooking to the future: Research at The Ross
The Ross Eye Institute Vision Research Center
Part of the Ross Eye Institute, the UB Department of Ophthalmology is committed to excellence in research, medical education, and healthcare.
Our research leads to sight-preserving treatments for conditions and diseases such as age-related macular degeneration, diabetic retinopathy and glaucoma. Our goal is to reduce visual impairment and improve the quality of life for people of all ages.
Ross researchers collaborate with scientists from over a dozen other universities, as well as domestic and international private research institutes and pharmaceutical companies. We also participate in the SUNY Eye Institute, a SUNY-wide eye research consortium represented by the four SUNY medical centers and the College of Optometry.
Our Research Faculty
Click on any doctor’s photo to learn more about their research and our laboratory efforts.
Steven J. Fliesler,
Josh J. Wang,
Sarah Xin Zhang,
Distinguished Lectures in Vision Science 2021
February 18, 2021
J. Mark Petrash, PhD
Professor and Vice Chair for Research Department of Ophthalmology
University of Colorado School of Medicine, Aurora CO
Lecture Title: “Pathogenesis and Novel Therapies for Cataracts and Lens Disorders”
Host: Jack M. Sullivan, MD, PhD (email@example.com)
March 11, 2021
Elia Duh, MD
Professor of Ophthalmology Wilmer Eye Institute
Johns Hopkins University, Baltimore, MD
Lecture Title: “Semaphorin 6A and Vascular Health in Ischemic Retinopathies”
Host: Margaret DeAngelis, PhD (firstname.lastname@example.org)
April 15, 2021
Constance Cepko, PhD
Professor of Ophthalmology
Bullard Professor of Genetics and Neuroscience
Harvard Medical School, Boston, MA
Investigator, Howard Hughes Medical Institute
Web: https://eye.hms.harvard.edu/conniecepko; https://www.hhmi.org/scientists/constance-l-cepko
Lecture Title: “Development and Degeneration of Retinal Photoreceptor Cells”
Host: Xiuqian Mu, MD, PhD (email@example.com)
May 20, 2021
Paul Sternberg, Jr., M.D.
G.W. Hale Professor & Chairman Department of Ophthalmology
Vanderbilt University, Nashville, TN
Lecture Title: “Regenerative Visual Neuroscience: How It Will Transform Eye Care”
Or “Anti-VEGF Treatment for Retinal Diseases: Past, Present, and Future”
Host: Steve Fliesler, PhD (firstname.lastname@example.org)
Summary of Research Programs
Fliesler Lab Research
Our lab is focused on studies of retinal degenerations caused by defects in isoprenoid biosynthesis. Our primary focus concerns how defective cholesterol metabolism (e.g., Smith-Lemli-Opitz syndrome, or SLOS) affects the development and maintenance of normal retinal structure and function, using pharmacological and transgenic animal models. In addition, we are studying how defects in dolichol synthesis impact retinal structure and function, using novel genetic mouse models of RP59 that have either a mutation in, or deletion of, the gene that encodes DHDDS (dehydrodolicholdiphosphate synthase), which is required for dolichol synthesis and, hence, N-linked protein glycosylation. We also are studying the effects of acoustic blast overpressure on the structure and function of the retina, using a rat model that mimics mild traumatic brain injury (mTBI).