Buffalo & Amherst: 716.881.7900

Orchard Park: 716.677.6500

Buffalo & Amherst: 716.881.7900
Orchard Park: 716.677.6500

The Ross Eye Institute Vision Research Center

Looking to the future: Research at The Ross

Research at the Ross Vision Research CenterThe Ross Eye Institute Vision Research Center

Part of the Ross Eye Institute, the UB Department of Ophthalmology is committed to excellence in research, medical education, and healthcare.

Our research leads to sight-preserving treatments for conditions and diseases such as age-related macular degeneration, diabetic retinopathy and glaucoma. Our goal is to reduce visual impairment and improve the quality of life for people of all ages.

Ross researchers collaborate with scientists from over a dozen other universities, as well as domestic and international private research institutes and pharmaceutical companies. We also participate in the SUNY Eye Institute, a SUNY-wide eye research consortium represented by the four SUNY medical centers and the College of Optometry.

Our Research Faculty

Click on any doctor’s photo to learn more about their research and our laboratory efforts.

Dr. Steven J. Fliesler

Steven J. Fliesler,

Dr. Xiuqian Mu

Xiuqian Mu,

Dr. Sangita Patel

Sangita Patel,

Dr. Jack Sullivan

Jack Sullivan,

Dr. Josh J. Wang

Josh J. Wang,

Dr. Sarah Xin Zhang

Sarah Xin Zhang,

Distinguished Lectures in Vision Science 2021


February  18, 2021
J. Mark Petrash, PhD
Professor and Vice Chair for Research Department of Ophthalmology
University of Colorado School of Medicine, Aurora CO
Web: https://medschool.cuanschutz.edu/ophthalmology/research/laboratory-research/faculty/mark-petrash
PubMed: https://www.ncbi.nlm.nih.gov/pubmed/?term=Petrash+JM
Lecture Title: “Pathogenesis and Novel Therapies for Cataracts and Lens Disorders”
Host: Jack M. Sullivan, MD, PhD (js354@buffalo.edu)

March 11, 2021
Elia Duh, MD
Professor of Ophthalmology Wilmer Eye Institute
Johns Hopkins University, Baltimore, MD
Web: https://www.hopkinsmedicine.org/profiles/results/directory/profile/0008957/elia-duh
PubMed: https://www.ncbi.nlm.nih.gov/pubmed/?term=elia+duh
Lecture Title: “Semaphorin 6A and Vascular Health in Ischemic Retinopathies”
Host: Margaret DeAngelis, PhD (mmdeange@buffalo.edu)

April 15, 2021
Constance Cepko, PhD
Professor of Ophthalmology
Bullard Professor of Genetics and Neuroscience
Harvard Medical School, Boston, MA
Investigator, Howard Hughes Medical Institute
Web: https://eye.hms.harvard.edu/conniecepko; https://www.hhmi.org/scientists/constance-l-cepko
PubMed: https://www.ncbi.nlm.nih.gov/pubmed/?term=Cepko+C
Lecture Title: “Development and Degeneration of Retinal Photoreceptor Cells”
Host: Xiuqian Mu, MD, PhD (xmu@buffalo.edu)

May 20, 2021
Paul Sternberg, Jr., M.D.
G.W. Hale Professor & Chairman Department of Ophthalmology
Vanderbilt University, Nashville, TN
Web: https://www.vumc.org/ophthalmology/person/paul-sternberg-jr-md
PubMed: https://www.ncbi.nlm.nih.gov/pubmed/?term=Paul+Sternberg+Jr
Lecture Title: “Regenerative Visual Neuroscience: How It Will Transform Eye Care”
Or “Anti-VEGF Treatment for Retinal Diseases: Past, Present, and Future”
Host: Steve Fliesler, PhD (fliesler@buffalo.edu)

Summary of Research Programs

Fliesler Lab Research

Our lab is focused on studies of retinal degenerations caused by defects in isoprenoid biosynthesis. Our primary focus concerns how defective cholesterol metabolism (e.g., Smith-Lemli-Opitz syndrome, or SLOS) affects the development and maintenance of normal retinal structure and function, using pharmacological and transgenic animal models. In addition, we are studying how defects in dolichol synthesis impact retinal structure and function, using novel genetic mouse models of RP59 that have either a mutation in, or deletion of, the gene that encodes DHDDS (dehydrodolicholdiphosphate synthase), which is required for dolichol synthesis and, hence, N-linked protein glycosylation. We also are studying the effects of acoustic blast overpressure on the structure and function of the retina, using a rat model that mimics mild traumatic brain injury (mTBI).

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    Buffalo Niagara
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    3580 Sheridan Drive
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    Your vision is of utmost importance to us.

    At the Ross Eye Institute, we understand the importance of continuing to meet your vision care needs. We take your health and COVID-19 precautions very seriously. Your health, and ours is of utmost importance.

    - We follow the Department of Health guidelines.
    - Doctors and staff undergo daily screening questions as well as temperature checks twice a day.
    - Access to our facility is limited to our patients only. If a patient cannot attend their appointment on their own, an escort will also be permitted.
    - Patients who arrive more than 15 minutes prior to their appointment will not be allowed inside until it gets closer to their scheduled appointment time. Please plan accordingly.
    - Patient and staff touch points are sanitized between each use and logs are maintained documenting strict adherence.
    - Proper mask use is strictly enforced.
    - We are not allowing visits from pharmaceutical reps, vendors, or other salespersons or business associates.

    Your vision care is a critical component to maintaining long-term vision health and the Ross Eye Institute remains committed to meeting your vision care needs while keeping you safe, during these uncertain times.