Steven J. Fliesler, PhD
Vision Research Center
Medical Research Service
Veterans Affairs Medical Center
Building 20, Room 202
3495 Bailey Ave.
Buffalo, NY 14215
Title and Department:
Meyer Riwchun Endowed Chair Professor, Vice-Chairman and Director of Research, Department of Ophthalmology
Professor (secondary), Department of Biochemistry
Education and Training:
Ph.D. in Biochemistry, Rice University, Houston, TX
Postdoctoral (Retinal Biochemistry/Cell Biology):
Cullen Eye Institute, Baylor College of Medicine,
Our lab is focused on studies of retinal degenerations caused by metabolic defects, particularly dyslipidemias involving defective cholesterol metabolism (e.g., Smith-Lemli-Opitz syndrome), using pharmacological and transgenic animal models. Current studies are focused on the role of lipid and protein oxidation in the underlying mechanisms of photoreceptor cell death in such retinal degenerations, using a combination of genomic, proteomic and lipidomic approaches.