Buffalo & Amherst: 716.881.7900

Orchard Park: 716.677.6500

Buffalo & Amherst: 716.881.7900
Orchard Park: 716.677.6500
info@rosseyeinstitute.com
Xiuqian Mu, MD, PhD - Vision Research Center

Xiuqian Mu, MD, PhD

Vision Research Center

Contact:
Center of Excellence
Room B4-319
701 Ellicott St.
Buffalo, NY 14203
Phone: 716-881-7463
Email: xmu@buffalo.edu

Title and Department:
Associate Professor
Department of Ophthalmology/Ross Eye Institute

Education and Training:
M.D. Qingdao Medical College, Qingdao, Shandong, China
Ph.D. (Biochemistry), Peking Union Medical College; Beijing, China

Postdoctoral (Biochemistry & Molecular Biology):
University of Texas M.D. Anderson Cancer Center, Houston, TX

Research Interest:

Dr. Xiuqian Mu, M.D., Ph.D. is interested in how global gene expression advances from one state to the next in time and space during development to promote the specification and differentiation of individual retinal cell types from multi-potent neural progenitor cells. We focus on the gene regulatory network (GRN) involved in the formation of one retinal cell type, retinal ganglion cells (RGCs). RGCs are the only projection neurons in the retina and connect the retina to the brain through the optic nerve. Death of RGCs is cause of vision loss in glaucoma and other retinal diseases.

Several key transcription factors (TFs) functioning at different stages of RGC development have been identified. Math5 is essential for RGC fate specification, whereas Pou4f2 and Isl1 are required for their differentiation. Our previous study has established a tentative model for the RGC GRN, in which these TFs occupy key node positions.

Current projects in the lab are aimed at further understanding how these transcription factors specifically regulate their target genes and how they interact with each other. Considerable efforts are also placed on identifying novel key regulators in the GRN. Our studies employ a combined approach of genetics, genomics and bioinformatics. Our eventual goal is to use the knowledge learned from our studies to develop new therapies for various retinal diseases.

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Your vision is of utmost importance to us.

At the Ross Eye Institute, we understand the importance of continuing to meet your vision care needs. We take your health and COVID-19 precautions very seriously. Your health, and ours is of utmost importance.

- We follow the Department of Health guidelines.
- Doctors and staff undergo daily screening questions as well as temperature checks twice a day.
- Access to our facility is limited to our patients only. If a patient cannot attend their appointment on their own, an escort will also be permitted.
- Patients who arrive more than 15 minutes prior to their appointment will not be allowed inside until it gets closer to their scheduled appointment time. Please plan accordingly.
- Patient and staff touch points are sanitized between each use and logs are maintained documenting strict adherence.
- Proper mask use is strictly enforced.
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Your vision care is a critical component to maintaining long-term vision health and the Ross Eye Institute remains committed to meeting your vision care needs while keeping you safe, during these uncertain times.